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Harmine | MAO-A and DYRK inhibitor

Harmine (343-27-1) is a selective competitive and reversible inhibitor of MAO-A (IC50 = 8 μM).1 Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC50's: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 μM; DYRK4 = 80 μM).2,3 Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells (GSLC's) possibly via inhibition of Akt phosphorylation.4 Harmine has also been shown to possess antimicrobial, antifungal, antiplasmodial, antitumor, antioxidant, antimutagenic and antigenotoxic properties.5 Inhibits osteoclast differentiation and bone resorption via downregulation of c-Fos and NFATc1 induced by RANKL.6

1) Wouters (1998) Structural Aspects of Monoamine Oxidase and its Reversible Inhibition Current Medicinal Chemistry, 5 137
2) Seifert et al. (2008) DYRK1A phosphorylates caspase 9 at an inhibitory site and is potentnly inhibited in human cells by harmine; FEBS J., 275 6268
3) Gockler et al. (2009) Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite outgrowth; FEBS J., 276 6324
4) Liu et al. (2013) Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of gliobalstoma; J .Neurooncol., 112 39
5) Patel et al. (2012) A review on medical importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid 'Harmine'; Asian Pac. J. Trop. Biomed., 2 660
6) Yoneazwa et al. (2011) Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo; Eur. J. Pharmacol., 650 511

Focus Biomolecules cell signaling reagent supplier, chemical structure of Harmine | MAO-A and DYRK inhibitor | CAS 343-27-1

Catalog#  10-4520

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Catalog Number:
MAO-A and DYRK inhibitor
Chemical Name:
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole hydrochloride
Molecular Weight:
Molecular Formula:
C13H12N2O HCl
Soluble in Water (up to 25 mg/ml).
Physical Properties:
White solid
>98% by TLC
Storage Temperature:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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