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Herbimycin A | HSP90 Inhibitor

Herbimycin A (70563-58-5) is an ansamycin antibiotic. Inhibits HSP90 and associated client proteins including v-Src, Bcr-Abl, Raf-1 and ErbB21,2. Herbimycin A reverts tyrosine kinase-induced oncogenic transformation without direct inhibition of phosphorylation activity1. Inhibits angiogenesis in a rat retinopathy model3.

References/Citations - Herbimycin A
1) Whitesell et al. (1994), Inhibition of heat shock protein HSP-90-pp60vsrc heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation; Proc. Natl. Acad. Sci. USA, 91 8324
2) Blagosklonny et al. (2002), Hsp-90-associated oncoproteins: multiple targets of geldanamycin and it's analogs; Leukemia, 16 455
3) GW McCollum et al. (2004), Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity; Exp. Eye Res., 78 987

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Catalog#  10-2567

$140.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
70563-58-5
Catalog Number:
10-2567
Activity:
HSP90 Inhibitor
Chemical Name:
(15R)-17-Demethoxy-15 methoxy-11-O-methyl-geldanamycin
Molecular Weight:
574.68
Molecular Formula:
C30H42N2O9
Solubility:
Soluble in DMSO (up to 6 mg/ml).
Physical Properties:
Yellow lyophilized solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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