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Herbimycin A | HSP90 Inhibitor

Herbimycin A (70563-58-5) is an ansamycin antibiotic. Inhibits HSP90 and associated client proteins including v-Src, Bcr-Abl, Raf-1 and ErbB21,2. Herbimycin A reverts tyrosine kinase-induced oncogenic transformation without direct inhibition of phosphorylation activity1. Inhibits angiogenesis in a rat retinopathy model3.

References/Citations - Herbimycin A
1) Whitesell et al. (1994), Inhibition of heat shock protein HSP-90-pp60vsrc heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation; Proc. Natl. Acad. Sci. USA, 91 8324
2) Blagosklonny et al. (2002), Hsp-90-associated oncoproteins: multiple targets of geldanamycin and it's analogs; Leukemia, 16 455
3) GW McCollum et al. (2004), Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity; Exp. Eye Res., 78 987

Focus Biomolecules cell signaling reagent supplier, chemical structure of Herbimycin A | HSP90 Inhibitor | CAS 70563-58-5

Catalog#  10-2567

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Catalog Number:
HSP90 Inhibitor
Chemical Name:
(15R)-17-Demethoxy-15 methoxy-11-O-methyl-geldanamycin
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 6 mg/ml).
Physical Properties:
Yellow lyophilized solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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