HOIPIN-8 | LUBAC inhibitor

Available Options

Size:PriceQuantity 
1 mg$50.00
5 mg$190.00
Request Quote / Bulk / Custom Size
Product Inquiry

HOIPIN-8 (2519537-70-1) is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC), IC50=11 nM.1   HOIPIN-8 suppresses proinflammatory cytokine-induced canonical NF-kB pathway as well as various pathogen-associated molecular pattern-induced antiviral pathways.2 It is a useful tool to assist in unraveling the physiological functions of LUBAC.3,4

References/Citations:

  1. Katsuya et al. (2019), Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling; Biochem. Biophys. Res. Commun. 509 700
  2. Oikaxa et al. (2020), Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses; Commun. Biol. 3 163
  3. Hoshino et al. (2024), RNF31 promotes proliferation and invasion of hepatocellular carcinoma via nuclear factor kappaB activation; Sci. Rep. 14 346
  4. Hua et al. (2021), Linear Ubiquitination Mediates EGFR-Induced NF-κB Pathway and Tumor Development; Int. J. Mol. Sci. 22 11875
2519537-70-1, HOIPIN-8, HOIPIN-8 supplier, LUBAC inhibitor

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

HOIPIN-8 (2519537-70-1) is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC), IC50=11 nM.1   HOIPIN-8 suppresses proinflammatory cytokine-induced canonical NF-kB pathway as well as various pathogen-associated molecular pattern-induced antiviral pathways.2 It is a useful tool to assist in unraveling the physiological functions of LUBAC.3,4

References/Citations:

  1. Katsuya et al. (2019), Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling; Biochem. Biophys. Res. Commun. 509 700
  2. Oikaxa et al. (2020), Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses; Commun. Biol. 3 163
  3. Hoshino et al. (2024), RNF31 promotes proliferation and invasion of hepatocellular carcinoma via nuclear factor kappaB activation; Sci. Rep. 14 346
  4. Hua et al. (2021), Linear Ubiquitination Mediates EGFR-Induced NF-κB Pathway and Tumor Development; Int. J. Mol. Sci. 22 11875