HOIPIN-8 | LUBAC inhibitor

CAS:
 2519537-70-1
Catalog Number:
 10-5642

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5 mg$190.00
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HOIPIN-8 (2519537-70-1) is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC), IC50=11 nM.1   HOIPIN-8 suppresses proinflammatory cytokine-induced canonical NF-kB pathway as well as various pathogen-associated molecular pattern-induced antiviral pathways.2 It is a useful tool to assist in unraveling the physiological functions of LUBAC.3,4

References/Citations:

  1. Katsuya et al. (2019), Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling; Biochem. Biophys. Res. Commun. 509 700
  2. Oikaxa et al. (2020), Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses; Commun. Biol. 3 163
  3. Hoshino et al. (2024), RNF31 promotes proliferation and invasion of hepatocellular carcinoma via nuclear factor kappaB activation; Sci. Rep. 14 346
  4. Hua et al. (2021), Linear Ubiquitination Mediates EGFR-Induced NF-κB Pathway and Tumor Development; Int. J. Mol. Sci. 22 11875
2519537-70-1, HOIPIN-8, HOIPIN-8 supplier, LUBAC inhibitor
CAS:
2519537-70-1
Catalog Number:
10-5642
Activity:
LUBAC inhibitor
Chemical Names:
(E)-2-(3-(2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl)-3-oxoprop-1-en-1-yl)-4-(1-methyl-1H-pyrazol-4-yl)benzoate, sodium salt
Molecular Weight:
456.38
Molecular Formula:

C23H15F2N4O3·Na

Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Beige solid
Purity:

>98% TLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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HOIPIN-8 (2519537-70-1) is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC), IC50=11 nM.1   HOIPIN-8 suppresses proinflammatory cytokine-induced canonical NF-kB pathway as well as various pathogen-associated molecular pattern-induced antiviral pathways.2 It is a useful tool to assist in unraveling the physiological functions of LUBAC.3,4

References/Citations:

  1. Katsuya et al. (2019), Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling; Biochem. Biophys. Res. Commun. 509 700
  2. Oikaxa et al. (2020), Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses; Commun. Biol. 3 163
  3. Hoshino et al. (2024), RNF31 promotes proliferation and invasion of hepatocellular carcinoma via nuclear factor kappaB activation; Sci. Rep. 14 346
  4. Hua et al. (2021), Linear Ubiquitination Mediates EGFR-Induced NF-κB Pathway and Tumor Development; Int. J. Mol. Sci. 22 11875

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