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HPI-1 | Hedgehog pathway inhibitor

HPI-1 (599150-20-6) is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. HPI-1 inhibits both endogenous and exogenous Gli1/Gli2 activity. IC50's range from 0.2 to 6 μM for various cell-based assays.

1) Hyman 0et al. (2009) Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade; Proc. Natl. Acad. Sci.USA, 106 14132

Focus Biomolecules cell signaling reagent supplier, chemical structure HPI-1 | Hedgehog pathway inhibitor | CAS 599150-20-6

Catalog#  10-4522

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
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599150-20-6 (anhydrous)
Catalog Number:
Hedgehog pathway inhibitor
Chemical Name:
2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate
Molecular Weight:
463.52 (anhydrous)
Molecular Formula:
C27H29NO6 xH20
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
Yellow solid
>98% by TLC
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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