HSL119 | HUNK inhibitor

CAS:
 2231745-56-3
Catalog Number:
 10-4363
HSL119 chemical structure

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HSL119 (2231745-56-3) is an inhibitor of the hormonally upregulated neu-associated kinase (HUNK); IC50 = 1.7 µM.  It inhibits several other kinases including ABL1, BRAF, FLT3, and RET.  HSL119 displays antitumor activity in several HER2/neu+ breast cancer models.

References/Citations:

  1. Dilday et al. (2024), Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer; Cell. Chem. Biol. 31 989
2231745-56-3, HSL-119, HSL119, HSL119 supplier, HUNK inhibitor
CAS:
2231745-56-3
Catalog Number:
10-4363
Activity:
HUNK inhibitor
Chemical Names:
3-((8-Amino-1,7-naphthyridin-5-yl)ethynyl)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
Molecular Weight:
544.58
Molecular Formula:

C30H27F3N6O

Solubility:
Soluble in DMSO (at least 75 mg/ml)
Physical Properties:
Yellow solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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HSL119 (2231745-56-3) is an inhibitor of the hormonally upregulated neu-associated kinase (HUNK); IC50 = 1.7 µM.  It inhibits several other kinases including ABL1, BRAF, FLT3, and RET.  HSL119 displays antitumor activity in several HER2/neu+ breast cancer models.

References/Citations:

  1. Dilday et al. (2024), Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer; Cell. Chem. Biol. 31 989

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