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Product Details

HTS01037 | FABP inhibitor

HTS01037 (682741-29-3) inhibits fatty acid binding proteins.  Inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages.  Acts as an antagonist of the protein-protein interaction between AFABP/aP2 and hormone sensitive lipase but does not activate PPARg in macrophages1. Inhibits FABP-dependent and fatty acid-stimulated leukotriene C4 biosynthesis2.  Reduces intracellular free fatty acid levels, lowering macrophage inflammation and ER stress3. Reduces LPS-stimulated IL-1b secretion in a mouse model4. Inhibits VLDL-induced foam cell formation5.

References/Citations

1) Hertzel et al. (2009), Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins; J. Med. Chem, 52 6024
2) Long et al. (2012), Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner; Biochim. Biophys. Acta, 1831 1199
3) Xu et al. (2015), Uncoupling lipid metabolism from inflammation through fatty acid binding protein-dependent expression of USP2; Mol. Cell. Biol., 35 1055
4) Steen et al. (2016), FABP4/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2; Mol. Cell. Biol., Epub ahead of print, Oct. 17
5) Boss et al. (2015), FABP4 inhibition suppresses PPARgamma activity and VLDL-induced foam cell formation in IL-4-polarized human macrophages; Atherosclerosis, 240 424

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HTS01037 | 682741-29-3 | Structure | Supplier

Catalog#  10-1453-0005

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
682741-29-3
Catalog Number:
10-1453
Activity:
FABP inhibitor
Chemical Name:
4-[(3-Carboxy-1-oxo-2-propen-1-yl)amino]-[2,2’-bithiophene]-5-carboxylic acid, 5-methyl ester
Molecular Weight:
337.37
Molecular Formula:
C14H11NO5S2
Solubility:
Soluble in DMSO (up to 50 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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