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Product Details

Lovastatin | HMG-CoA reductase inhibitor

Lovastatin (75330-75-5) Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase (Ki=1nM for acid form).1,2 Induces apoptosis in various cell lines.3 Causes cell cycle arrest in early G1 phase.4 Lovastatin is a clinically useful antihyperlipemic agent.5 Cell permeable.

References/Citations

1) Alberts et al. (1988), Discovery, biochemistry and biology of lovastatin;  Am. J. Cardiol., 62 10J
2) Hancock et al. (1989), All ras proteins are polyisoprenylated but only some are palmitoylated;  Cell, 57 1167
3) Park et al. (1999), Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis;  Anticancer Res., 19 3133
4) Vilimanovich et al. (2015), Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells;  Eur. J. Pharmacol., 765 415
5) Tobert et al. (1988), Efficacy and long-term adverse effect pattern of lovastatin;  Am. J. Cardiol., 62 28J

 

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Lovastatin | 75330-75-5 | Structure | Supplier

Catalog#  10-1222

$41.00
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CAS:
75330-75-5
Catalog Number:
10-1222
Activity:
HMG-CoA reductase inhibitor
Alternate Names:
Mevinolin
Chemical Name:
2-Methyl-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acid
Molecular Weight:
404.55
Molecular Formula:
C24H36O5
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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