Lovastatin (75330-75-5) Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase (Ki=1nM for acid form).1,2 Induces apoptosis in various cell lines.3 Causes cell cycle arrest in early G1 phase.4 Lovastatin is a clinically useful antihyperlipemic agent.5 Cell permeable.
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3) Park et al. (1999), Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis; Anticancer Res., 19 3133
4) Vilimanovich et al. (2015), Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells; Eur. J. Pharmacol., 765 415
5) Tobert et al. (1988), Efficacy and long-term adverse effect pattern of lovastatin; Am. J. Cardiol., 62 28J