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Product Details

Hymeglusin | Melvalonate biosynthesis inhibitor

Hymeglusin (29066-42-0) is a inhibitor of eukaryotic mevalonate biosynthesis via inhibition of HMG-CoA synthase, IC50=0.12 mM.1 Acts via covalent modification of the active site Cys129.1,2 Inhibits cholesterol biosynthesis in rats (45% at 25 mg/Kg),1 Also inhibits bacterial HMG-CoA synthase.3 Inhibits dengue virus replication.4

References/Citations

1) Greenspan et al. (1987), Inhibition of hydroxymethylglutaryl-coenzyme A sunthase by L-659,699; Proc. Natl. Acad. Sci. USA, 84 7488
2) Tomoda et al. (2004), Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase; Biochem. Biophys. Acta, 1636 22
3) Skaff et al. (2012), Biochemical and structural basis for inhibition of Enterococcis faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin; Biochemistry, 51 4713
4) Rothwell et al. (2009), Cholesterol biosynthesis modulation regulates dengue viral replication; Virology, 389 8

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Catalog#  10-3289-0001

$200.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
29066-42-0
Catalog Number:
10-3289
Activity:
Melvalonate biosynthesis inhibitor
Chemical Name:
11-[3R-(Hydroxymethyl)-4-oxo-2R-oxetanyl]-3,5,7R-trimethyl-2E,4E-undecadienoic acid
Alternate Names:
L-659699; Antibiotic 1233A; Antibiotic F244
Molecular Weight:
324.41
Molecular Formula:
C18H28O5
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
96% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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