Hypoxanthine | Nutrient additive for cell culture
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 g | $35.00 | ||
| 25 g | $70.00 |
Hypoxanthine (68-94-0) is a natural purine analog and a breakdown product of adenosine.1 Together with aminopterin and thymidine, it is a component of HAT medium2, which is used to select clones during recombinant protein and antibody production, particularly important in bioprocessing. It is a biomarker of ischemia2,3, and it is used in malaria research as an essential nutrient for P. Falciparum4. It also can enable stem cell expansion.5
References/Citations:
- Chen and Sorgensen (1956), Formation of hypoxanthine from adenosine triphosphate in shed human blood; Acta Pharmacol. Toxicol. (Copenh), 12 369
- Migeon and Miller (1968), Human-mouse somatic cell hybrids with single human chromosome (group E): link with thymidine kinase activity; Science 162 1005
- Von Holst and Sollevi (1985), Increased concentration of hypoxanthine in human central cerebrospinal fluid after subarachnoid haemorrhage; Acta Neurochir. (Wien) 77 52
- Tewari et al. (2019), Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability; Malar. J. 18 Article number 86
- Huhi et al. (2011), SACK-expanded hair follicle stem cells display asymmetric nuclear Lgr5 expression with non-random sister chromatid segregation; Sci. Rep. 1 176
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Hypoxanthine (68-94-0) is a natural purine analog and a breakdown product of adenosine.1 Together with aminopterin and thymidine, it is a component of HAT medium2, which is used to select clones during recombinant protein and antibody production, particularly important in bioprocessing. It is a biomarker of ischemia2,3, and it is used in malaria research as an essential nutrient for P. Falciparum4. It also can enable stem cell expansion.5
References/Citations:
- Chen and Sorgensen (1956), Formation of hypoxanthine from adenosine triphosphate in shed human blood; Acta Pharmacol. Toxicol. (Copenh), 12 369
- Migeon and Miller (1968), Human-mouse somatic cell hybrids with single human chromosome (group E): link with thymidine kinase activity; Science 162 1005
- Von Holst and Sollevi (1985), Increased concentration of hypoxanthine in human central cerebrospinal fluid after subarachnoid haemorrhage; Acta Neurochir. (Wien) 77 52
- Tewari et al. (2019), Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability; Malar. J. 18 Article number 86
- Huhi et al. (2011), SACK-expanded hair follicle stem cells display asymmetric nuclear Lgr5 expression with non-random sister chromatid segregation; Sci. Rep. 1 176
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