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Product Details

ICA-110381 | Kv7.2/7.3 activator

ICA-110381 (325457-99-6) is a KCNQ2/Q3 (Kv7.2/7.3) activator, EC50=0.38 μM (KCNQ1 IC50=15 μM)1. KCNQ3/Q5 heterodimers are not affected2. Potently dampens neuronal excitability and displays anticonvulsant activity in vivo2.

References/Citations
1) Amato et al. (2011), N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy; Sci. ACS Med. Chem. Lett., 2 481
2) Boehlen et al. (2013), The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)benzamid displays anticonvulsant potential; Br. J. Pharmacol., 168 1182

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Focus Biomolecules cell signaling reagent supplier, chemical structure of ICA-11381 | Kv7.2/7.3 activator | CAS 325457-99-6

Catalog#  10-1467

$55.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
325457-99-6
Catalog Number:
10-1467
Activity:
Kv7.2/7.3 activator
Chemical Name:
4-Chloro-N-(6-chloro-3-pyridinyl)benzamide
Molecular Weight:
267.12
Molecular Formula:
C12H8Cl2N2O
Solubility:
Soluble in DMSO (up to 26 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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