my account
Login
  Loading... Please wait...

Product Details

ICG-001 | Wnt beta-catenin inhibitor

ICG-001 (847591-62-2) inhibits TCF/β-catenin mediated transcription by specifically blocking β-catenin/CBP interaction

References/Citations

1) Emami et al. (2004), A small molecule inhibitor of β-catenin/CREB-binding protein transcription;  Proc. Natl. Acad. Sci. USA, 101 12682
2) Zhou et al. (2012), Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcription co-activator cAMP-response element-binding protein (CERB)-binding protein (CBP);  J. Biol. Chem., 287 7026

swipe
Focus Biomolecules cell signaling supplier, chemical structure of ICG-001 | Wnt beta-catenin inhibitor | CAS 847591-62-2

Catalog#  10-4378

$65.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
847591-62-2
Catalog Number:
10-4378
Activity:
Wnt β-catenin inhibitor
Chemical Name:
(6S,9aS)-Hexahydro-6-[(4-hydroxypheny;)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H- pyrazine[1,2-a]pyrimidine-1(6H)-carboxamide
Molecular Weight:
548.63
Molecular Formula:
C33H32N4O4
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the ICG-001 | Wnt beta-catenin inhibitor to your wish list.