Icilin | TRPM8 activator
NMR (conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $65.00 | ||
| 50 mg | $245.00 |
Icilin (36945-98-9) is an activator of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 μM for CRM1, rat orthologue of TRPM8).1 Activator at TRPM8 (EC50 = 0.2 μM)2 and ANKTM1(TRPA1)3. Activator effects require Ca2+ and are pH dependent.2,4 Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.5
References/Citations:
1) McKemy et al. (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation; Nature, 416 52
2) Andersson et al. (2004) TRPM8 activation by menthol, icilin and cold is differentially modulated by intracellular pH; J .Neurosci., 24 5364
3) Story et al. (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures; Cell, 112 819
4) Chuang et al. (2004) The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel; Neuron, 43 859
5) Kim et al. (2011) Icilin induces G1 arrest through activating JNK and p38 kinase in a TRPM8-independent manner; Biochem. Biophys. Res .Commun., 406 30
NMR (conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Icilin (36945-98-9) is an activator of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 μM for CRM1, rat orthologue of TRPM8).1 Activator at TRPM8 (EC50 = 0.2 μM)2 and ANKTM1(TRPA1)3. Activator effects require Ca2+ and are pH dependent.2,4 Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.5
References/Citations:
1) McKemy et al. (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation; Nature, 416 52
2) Andersson et al. (2004) TRPM8 activation by menthol, icilin and cold is differentially modulated by intracellular pH; J .Neurosci., 24 5364
3) Story et al. (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures; Cell, 112 819
4) Chuang et al. (2004) The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel; Neuron, 43 859
5) Kim et al. (2011) Icilin induces G1 arrest through activating JNK and p38 kinase in a TRPM8-independent manner; Biochem. Biophys. Res .Commun., 406 30
Related products
-
Amlodipine | L-type Ca channel blocker
From $30.00CAS:88150-42-9Catalog Number:10-1210Activity:L-type Ca channel blockerMolecular Weight:408.89Molecular Formula:C20H25ClN2O5Solubility:Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:98%
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Astemizole | hERG channel blocker
From $30.00CAS:68844-77-9Catalog Number:10-1064Activity:hERG channel blockerChemical Name:1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amineMolecular Weight:457.58Molecular Formula:C28H31FN4OSolubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Nifedipine | L-type Ca channel blocker
From $40.00CAS:21829-25-4Catalog Number:10-1116Activity:L-type Ca channel blockerChemical Name:2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl esterMolecular Weight:346.34Molecular Formula:C17H18N2O6Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions are not stable and must be used within one working day.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.