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Product Details

iCRT5 | Beta-catenin inhibitor

iCRT5 (18623-44-4) is a selective CRT (β-catenin-responsive transcription) inhibitor.1  IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the β-catenin, TCF4 interaction.1 Displays poor inhibition of cell proliferation in triple-negative breast cancer cells.2 Increases the surface expression of MHCII, CD80 and CD86 on unstimulated dendritic cells (DCs) with no detrimental effects on immune-phenotype of stimulated DCs.3 Modulators of Wnt signaling show great promise in animal models of several cancers.4 Cell permeable.

References/Citations

1) Gonsalves et al. (2011), An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway; Proc. Natl. Acad. Sci. USA, 108 5954
2) Bilir et al. (2013), Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells; J. Transl. Med., 11 280
3) Kafer et al. (2016), Inhibitors of β-catenin affect the immune-phenotype and functions of dendritic cells in an inhibitor-specific manner; Immunopharmacol., 32 118
4) Anastas et al. (2013), WNT signaling pathways as therapeutic targets in cancer; Nat. Rev. Cancer, 13 11

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Focus Biomolecules cell signaling reagent supplier, chemical structure of iCRT5 | Beta-catenin inhibitor | CAS 18623-44-4

Catalog#  10-1371-0005

$57.00
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CAS:
18623-44-4
Catalog Number:
10-1371
Activity:
Beta-catenin inhibitor
Chemical Name:
4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid
Molecular Weight:
367.44
Molecular Formula:
C16H17NO5S2
Solubility:
Soluble in DMSO (up to 30 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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