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Product Details

Imiquimod | TLR7 Agonist

Imiquimod (99011-02-6) is a Toll-like receptor 7/8 agonist with anti-viral and anti-tumor properties.1 Enhances innate immune system leading to Th1-mediated antitumor immune response.2 Increases levels of IFNα, TNFα, and IL-12. Imiquimod has also been shown to act as an antagonist at adenosine A1 and A2A receptors augmenting its proinflammatory effects.3,4 Clinically useful for the treatment of basal cell carcinoma, actinic keratosis, and genital warts.  Imiquimod also upregulates the expression of opioid growth factor receptor(OGFr).5,6 OGF is involved in regulation of inhibitory kinases in the cell cycle process.

References/Citations

1) Hemmi et al. (2002), Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway; Nat. Immunol. 3 196
2) Stanley et al. (2002), Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential; Clin. Exp. Dermatol. 27 571
3) Schoen et al. (2006), The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion; J.Invest.Dermatol. 126 1338
4) Kan et al. (2012), Imiquimod Suppresses Propagation of Herpes Simplex Virus 1 by Upregulation of Cystatin A via the Adenosine Receptor A1 Pathway.; J. Virol. 86 10338
5) Urosevic et al. (2004), Imiquimod Treatment Induces Expression of Opioid Growth Factor Receptor; Clin. Cancer Res. 10 4959
6) Zagon et al. (2008), Imiquimod Upregulates the Opioid Growth Factor Receptor to Inhibit Cell Proliferation Independent of Immune Function.; Exp. Biol. Med.(Maywood) 233 968

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Catalog#  10-4230-0050

$30.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
99011-02-6
Catalog Number:
10-4230
Alternate Name:
R837
Activity:
TLT7 agonist
Chemical Name:
1-(2-Methylpropyl)imidazo[4,5-c]quinolin-4-amine
Molecular Weight:
240.30
Molecular Formula:
C14H14N4
Solubility:
Soluble in DMSO (2 mg/ml with warming)
Physical Properties:
White solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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