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2′,3′-cGAMP | Endogenous STING agonist

CAS:
1441190-66-4
Catalog Number:
10-1639
Activity:
Endogenous STING agonist
Chemical Name:
Adenylyl-(3’5’)-2’guanylic acid, cyclic nucleotide, disodium salt
Alternate Name:
2′,3’cyclic GMP-AMP
Molecular Weight:
718.38
Molecular Formula:
C20H22N10O13P2·2Na
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

2′,3′-cGAMP (CAS 1441190-66-4) is an endogenous STING (stimulator of interferon genes) agonist.1 Produced from ATP and GTP via the action of cGMP-AMP synthase (cGAS) which acts as a cytosolic DNA sensor.2,3 Induces autophagy which is a mechanism for clearance of DNA and viruses in the cytosol.4 DNA damage stimulates 2’,3’-cGAMP which stimulates an inflammatory response.5

References/Citations:

1) Zhang et al. (2015), Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING; Mol. Cell 51 226
2) Wu et al. (2013), Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA; Science 339 826
3) Sun et al. (2013), Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway; Science 339 786
4) Gui et al. (2019), Autophagy induction via STING trafficking is a primordial function of the cGAS pathway;  Nature, 567 262
5) Li and Chen (2018), The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence and cancer;  J. Exp. Med., 215 1287

2′,3′-cGAMP | Endogenous STING agonist is also available in the Cellular Metabolism Library.
CAS:
1441190-66-4
Catalog Number:
10-1639
Activity:
Endogenous STING agonist
Chemical Name:
Adenylyl-(3’5’)-2’guanylic acid, cyclic nucleotide, disodium salt
Alternate Name:
2′,3’cyclic GMP-AMP
Molecular Weight:
718.38
Molecular Formula:
C20H22N10O13P2·2Na
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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