Intelliscreen™ Immunoregulatory Kinase Inhibitor Mini-Library
T cells, B cells, and innate immune system cells express cytokine and immune recognition receptors that are activated directly by kinase phosphorylation or adaptor molecules affected by kinases. Advances in kinase inhibitor selectivity have enabled researchers to target specific pathways in immune function leading to treatments for cancer, autoimmune, and inflammatory disorders. The IntelliscreenTM Immunoregulatory kinase Inhibitors mini-library offers a broad range of selective kinase inhibitors involved in immune and inflammatory pathways.
Catalog Number:
10-7335
Description:
21 Inhibitors of various immunoregulatory kinases
Solubility:
DMSO
Supplied As:
DMSO solution @ 10mM
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$550.00
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
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Acalabrutinib | Highly selective BTK inhibitor
From $45.00CAS:1420477-60-6Catalog Number:10-4806Alternate Name:ACP-196Activity:Highly selective BTK inhibitorChemical Name:4-[8-Amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamideMolecular Weight:465.52Molecular Formula:C26H23N7O2Solubility:Soluble in DMSO (up to at least 25 mg/ml)Physical Properties:Yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
AZD1208 | PIM
CAS:1204144-28-4Catalog Number:10-4781 -
Darovasertib | pan-PKC
CAS:1874276-76-2Catalog Number:10-4353 -
Defactinib | Potent FAK inhibitor
From $65.00CAS:1073154-85-4Catalog Number:10-4828Activity:Potent FAK inhibitorChemical Name:N-Methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]aminl]benzamideMolecular Weight:510.50Molecular Formula:C20H21F3N8O3SSolubility:Soluble in DMSO (up to at least 25mg/ml)Physical Properties:White solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°C (des.)Stability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Deucravacitinib | Allosteric TYK2 inhibitor
From $100.00CAS:1609392-27-9Catalog Number:10-4756Activity:Allosteric TYK2 inhibitorChemical Names:6-(Cyclopropanecarbonylamino)-4-[2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamideAlternate Name:BMS-986165Molecular Weight:425.47Molecular Formula:C20H19D3N8O3Solubility:Soluble in DMSO (25 mg/ml with warming); ethanol (20 mg/ml)Physical Properties:White to off-white solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
eFT508 | MNK1/2
CAS:1849590-01-7Catalog Number:10-4081 -
Galunisertib | Potent TGFB receptor 1 inhibitor / Cancer immunotherapeutic
From $45.00CAS:700874-72-2Catalog Number:10-4110Activity:Potent TGF-β receptor 1 inhibitor / Cancer immunotherapeuticChemical Name:4-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamideAlternate Names:LY2157299Molecular Weight:369.43Molecular Formula:C22H19N5OSolubility:Soluble in DMSO (up to 25 mg/ml)Physical Properties:White solidPurity:98%
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
GSK2982772 | RIP1 inhibitor
From $95.00CAS:1622848-92-3Catalog Number:10-4792Activity:RIP1 kinase inhibitorChemical Names:(S)-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl)-4H-1,2,4-traizole-3-carboxamide; GSK772Molecular Weight:377.40Molecular Formula:C20H19N5O3Solubility:Soluble in DMSO (>25 mg/ml)Physical Properties:Off-white solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
GSK8612 | Highly selective TBK1 inhibitor
From $65.00CAS:2361659-62-1Catalog Number:10-4693Activity:Highly selective TBK1 inhibitorChemical Names:4-[[[5-Bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]benzenesulfonamideMolecular Weight:520.33Molecular Formula:C17H17BrF3N7O2SSolubility:Soluble in DMSO (20 mg/ml)Physical Properties:Beige solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
HS276 | TAK1
CAS:2767422-72-8Catalog Number:10-4847 -
IPI-549 | Selective PI3Kgamma inhibitor / Immuno-oncology agent
From $50.00CAS:1693758-51-8Catalog Number:10-4827Activity:Selective PI3K-gamma inhibitor / Immuno-oncology agentChemical Name:(S)-2-Amino-N-[1-[8-[2-(1-methylpyrazol-4-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamideMolecular Weight:629.68Molecular Formula:C30H24N8O2Solubility:Soluble in DMSO (up to at least 25 mg/ml)Physical Properties:Pale yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
MLN120B | IKKß
CAS:783348-36-7Catalog Number:10-4830 -
NVP-BSK805 | JAK2
CAS:1310726-60-3Catalog Number:10-4375 -
P505-15 | SYK
CAS:1370261-97-4Catalog Number:10-4650 -
Pexidartinib | CSF1R inhibitor
From $45.00CAS:1029044-16-3Catalog Number:10-4829Activity:CSF1R inhibitor/Cancer immunotherapy enhancerChemical Name:5-[(5-Chloro-1H-pyrrolo[2,3.b]pyridine-3-yl)methyl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyridin-2-amineAlternate Names:PLX3397Molecular Weight:417.81Molecular Formula:C20H15ClF3N5Solubility:Soluble in DMSO (up to at least 10 mg/ml)Physical Properties:White solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.Shipping Code:RT -
R428 | Potent and selective AXL inhibitor
From $75.00CAS:1037624-75-1Catalog Number:10-4676Activity:Potent and selective AXL inhibitorChemical Name:1-(3,4-Diazatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-5-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamineAlternate Names:Bemcentinib; BGB324Molecular Weight:506.64Molecular Formula:C30H34N8Solubility:Soluble in DMSO (up to at least 25 mg/ml)Physical Properties:Yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Ritlecitinib | JAK3
CAS:1792180-81-4Catalog Number:10-4377 -
SGC-CK2-1 | CK2
CAS:2470424-39-4Catalog Number:10-4137 -
Umbralisib | PI3Kδ
CAS:1532533-67-7Catalog Number:10-4168 -
Upadacitinib | JAK1
CAS:1310726-60-3Catalog Number:10-4375 -
Zimlovisertib | IRAK4
CAS:1817626-54-2Catalog Number:10-4453
