my account
Login
  Loading... Please wait...

Product Details

Indirubin-3'-monoxime | GSK-3 beta and CDK inhibitor

Indirubin-3'-monoxime (160807-49-8) is a potent GSK-3β inhibitor (IC50=22 nM)1. Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM)1. Displays antimitotic properties and induces endoreplication following prophase arrest in HBL-100 cells2. Possesses antiangiogenic activity3. Indirubin-3'-monoxime attenuates β-amyloid-associated neuropathology in a mouse model of Alzheimer's disease4. Cell permeable.

References/Citations
1) Leclerc et al. (2001), Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?; J. Biol. Chem., 276 251
2) Damiens et al. (2001), Anti-mitotic properties of indirubin-3'-monoximine, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest; Oncogene, 20 3786
3) Kim et al. (2011), Indirubin-3'-monoxime, a derivative of a chinese antileukemia medicine, inhibits angiogenesis; J. Cell. Biochem., 112 1384
4) Ding et al. (2010), Indirubin-3'-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer's disease; Neurobiol. Dis., 39 156

swipe
Indirubin-3'-monoxime | 160807-49-8 | Structure | Supplier

Catalog#  10-1488

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
160807-49-8
Catalog Number:
10-1488
Activity:
GSK-3β and CDK inhibitor
Alternate Names:
Indirubin-3'oxime
Chemical Name:
3-[1,3-Dihydro-3-(hydroxyimino-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
Molecular Weight:
277.29
Molecular Formula:
C16H11N3O2
Solubility:
Soluble in DMSO (up to 6 mg/ml) or in Ethanol (up to 4 mg/ml).
Physical Properties:
Dark red or brown solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the Indirubin-3'-monoxime | GSK-3 beta and CDK inhibitor to your wish list.