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Product Details

Ingenol-3-angelate | PKC activator

Ingenol-3-angelate (75567-37-2) is a selective activator of protein kinase C which displays antileukemic activity mediated via PKCδ.1 In contrast, it provides a strong survival signal to resting and activated human T cells via activation of PKC and downstream activation of NFκB.2 Treatment of subcutaneous tumors results in anti-cancer CD8 T cells, also displays adjuvant activity and synergizes with cancer immunotherapies.3 Induces senescence-like growth arrest in solid tumor cells.4 Inhibits HIV-1 infection at an early pathway of viral entry.5

 

References/Citations

1) Hampson et al. (2005), PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC; Blood, 106 1362
2) Lee et al. (2010), Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta; J. Biol. Chem., 285 23889
3) Le et al. (2009), Immunostimulatory cancer chemotherapy using local ingenol-3-angelate and synergy with immunotherapies; Vaccine, 27 3053
4) Mason et al. (2010), The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells; Invest. New Drugs, 28 575
5) Warrilow et al. (2006), HIV type 1 inhibition by protein kinase C modulatory compounds; AIDS Res. Hum. Retroviruses, 22 854

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Catalog#  10-1244-0001

$110.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
75567-37-2
Catalog Number:
10-1244
Activity:
PKC activator
Alternate Names:
PEP-005
Molecular Weight:
460.53
Molecular Formula:
C25H34O6
Solubility:
Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 4 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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