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Product Details

Iniparib | PARP inhibitor

Iniparib (160003-66-7) was originally thought to be a PARP1 inhibitor but this is controversial.1,2 Inhibits ionizing radiation-induced single-stranded DNA break repair in lymphoid cell lines in vivo.3 Inhibits growth of certain breast cancer cell lines in vitro. Iniparib non-selectively modifies cysteine-containing proteins in tumor cells.4

References/Citations

1) Sinha et al. (2014), Downfall of iniparib: a PARP inhibitor that doesn’t inhibit PARP after all; J. Natl. Cancer Inst., 106 447
2) Mateo et al. (2013), Appraising iniparib, the PARP inhibitor that never was –what must we learn?; Nat. Rev. Clin. Oncol., 10 688
3) Ma et al. (2012), Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus; Proc. Natl. Acad. Sci. USA, 109 6590
4) Liu et al. (2012), Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor; Clin. Cancer Res., 18 510

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Catalog#  10-2574-0010

$65.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
160003-66-7
Catalog Number:
10-2574
Activity:
PARP inhibitor
Chemical Name:
4-Iodo-3-nitrobenzamide
Alternate Names:
BSI-201
Molecular Weight:
292.03
Molecular Formula:
C7H5IN2O3
Solubility:
Soluble in DMSO (up to 15 mg/ml) or Ethanol (up to 15 mg/ml
Physical Properties:
Yellow solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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