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Product Details

INK-128 | TORC1/2 inhibitor

INK-128 (1224844-38-5) is a potent and selective, ATP-competitive inhibitor of mTOR kinase, Ki = 1.4 nM.1 Inhibits growth and proliferation of various breast cancer cell lines and human endothelial cells.2

References/Citations

1) Hsieh et al. (2012), The translational landscape of mTOR signaling steers cancer initiation and metastasis; Nature, 485 55
2) Gokmen-Polar et al. (2012) Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent oral antitumor activity in human breast cancer xenograft models; Breast Cancer Res. Treat., 136 673

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Catalog#  10-3362

$46.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1224844-38-5
Catalog Number:
10-3362
Activity:
TORC1/2 inhibitor
Chemical Name:
3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Alternate Names:
MLN-0128
Molecular Weight:
309.33
Molecular Formula:
C15H15N7O
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC/HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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