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Ionomycin | Ca2+ ionophore

Ionomycin (56092-81-0) is a highly selective nonfluorescent calcium (Ca2+) ionophore.1 Induces a rapid rise in cytosolic Ca2+ in human neutrophils which is due to both release from cytosolic Ca2+ stores as well as Ca2+ influx.2 It activates (2 μM) and primes (20-200 nM) neutrophil NADPH oxidase2. Down regulates beta-catenin/Tcf signaling in a colon cancer cell line via suppressing the binding of Tcf to its specific DNA-binding site.3 In rat hepatoma cells, sub-lethal ionomycin activates the stress response by activating SAPK/JNK and HSF/HSE interaction leading to upregulation of HSP70 biosynthesis.4

References/Citations
1) Kaufmann et al., (1980) Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria; J. Biol. Chem. 255 2735
2) Elzi et al., (2001) Inonmycin causes actiivation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils; Am. J. Physiol. Cell Physiol. 281 C350
3) Park et al., (2005) Ionomycin downregulates beta-catenin/tcf signaling in colon cancer cell line; Carcinogenesis, 26 1929
4) Sreedhar and Srinivas (2002) Activation of stress response by ionomycin in rat hepatoma cells; J. Cell Biochem., 86 154

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Ionomycin | Ca2+ ionophore | CAS 56092-81-0

Catalog#  10-2079

$31.00
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CAS:
56092-81-0
Catalog Number:
10-2079
Activity:
Ca2+ ionophore
Molecular Weight:
709.01
Molecular Formula:
C41H72O9
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Yellow oil
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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