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Product Details

IQ-1S | JNK3 inhibitor

IQ-1S (1421610-21-0) is a JNK3 inhibitor (Kd = 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Displays anti-inflammatory and immunosuppresive activity. Inhibits LPS-induced proinflammatory cytokine and nitric oxide release in vitro.1 Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo.2

References/Citations

1) Schepetkin et al. (2012), Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors; Mol. Pharmacol., 81 832
2) Schepetkin et al. (2015), Anti-Inflammatory effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1A, a Selective c-Jun N-Terminal Kinase Inhibitor; J. Pharmacol. Exp. Ther., 353 505

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Catalog#  10-1513-0005

$40.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1421610-21-0
Catalog Number:
10-1513
Activity:
JNK3 inhibitor
Chemical Name:
11H-Indeno[1,2-b]quinoxaline-11-one oxime, sodium salt
Molecular Weight:
269.23
Molecular Formula:
C15H8N3O • Na
Solubility:
Soluble in DMSO (up to 15 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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