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Product Details

ISRIB | Integrated stress response inhibitor

ISRIB (1597403-47-8) is an integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM.1   Enhances spatial and fear-associated learning in mice and enhances cognitive function.1,2 Mechanism of action involves activation of eiF2β.3 Suppresses ER stress-induced inflammatory gene expression.4 Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production.5 Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.6

References/Citations

1) Sidrauski et al. (2013), Pharmacological brake-release of mRNA translation enhances cognitive memory; Elife, 2 e00498
2) Sekine et al. (2015), Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound; Science, 348 1027
3) Sidrauski et al. (2015), Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response; Elife, 4 e07314
4) Guthrie et al. (2016), Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-Induced Inflammation Without Compromising Immunological Responses; J. Biol. Chem., 291 15830
5) Hosoi et al. (2016), Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death; J. Pharmacol. Sci., 131 292
6) Chou et al. (2017), Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury; Proc. Natl. Acad. Sci. USA, 114 E6420

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Focus Biomolecules reagent supplier, chemical structure of ISRIB | Integrated stress response inhibitor | CAS 159403-47-8

Catalog#  10-1539-0005

$60.00
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CAS:
159403-47-8
Catalog Number:
10-1539
Activity:
Integrated stress response inhibitor
Chemical Name:
N.N’-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide
Alternate Names:
trans-ISRIB
Molecular Weight:
451.34
Molecular Formula:
C22H24Cl2N2O4
Solubility:
Soluble in DMSO (up to 5 mg/ml with warming)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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