ITD-1 | TGFß Degrader

CAS:
 1099644-42-4
Catalog Number:
 10-3707

Available Options

Size:PriceQuantity 
5 mg$70.00
25 mg$280.00
Request Quote / Bulk / Custom Size
Product Inquiry

ITD-1 (1099644-42-4) is a selective inhibitor of TGFß signaling (IC50=0.85 µM).1 Induces proteasomal degradation of TGFß type II receptor. Induces cardiomyocyte differentiation in embryonic stem cells.1,2

References/Citations:

  1. Willems et al. (2012), Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells; Cell Stem Cell, 11 242
  2. McKinney and McDevitt (2013), Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis; Trends Biotechnol., 31 78
1099644-42-4, ITD-1, ITD-1 supplier, ITD1, TGFß degrader
CAS:
1099644-42-4
Catalog Number:
10-3707
Activity:
TGFß degrader
Chemical Names:
4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester
Molecular Weight:
415.53
Molecular Formula:

C27H29NO3

Solubility:
Soluble in DMSO (8 mg/ml); Ethanol (4 mg/ml)
Physical Properties:
Yellow solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

ITD-1 (1099644-42-4) is a selective inhibitor of TGFß signaling (IC50=0.85 µM).1 Induces proteasomal degradation of TGFß type II receptor. Induces cardiomyocyte differentiation in embryonic stem cells.1,2

References/Citations:

  1. Willems et al. (2012), Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells; Cell Stem Cell, 11 242
  2. McKinney and McDevitt (2013), Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis; Trends Biotechnol., 31 78

STEM CELL

BOGO