ITI-214 | Selective PDE1 inhibitor

CAS:
 1642303-38-5
Catalog Number:
 10-4362
ITI-214 chemical structure

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ITI-214 (1642303-38-5) is an ultra-potent and selective inhibitor of phosphodiesterase 1 (PDE1) – Ki = 58 pM.1 Active in various animal models of motor and cognitive functions.1-3 It has also been shown to suppress inflammatory responses 4,5 and improve vascular function5.

References/Citations:

  1. Li al. (2016), Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases; J. Med. Chem., 59 1149
  2. Snyder al. (2016), Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats; Psychopharmacology (Berl), 233 3113
  3. Pekcec al. (2018), Targeting the dopamine D1 receptor or its downstream signalling by inhibiting phosphodiesterase-1 improves cognitive performance; Br. J. Pharmacol., 175 3021
  4. O’Brien al. (2020), Inhibition of calcium-calmodulin phosphodiesterase (PDE1) suppresses inflammatory responses; Mol. Cell Neurosci., 102 103449
  5. Golshiri al. (2021), Selective Phosphodiesterase 1 Inhibition Ameliorates Vascular Function, Reduces Inflammatory Response, and Lowers Blood Pressure in Aging Animals; J. Pharmacol. Exp. Ther., 378 173
1642303-38-5, ITI-214, ITI-214 supplier, Lenrispodun, Lenrispodun phosphate, Lenrispodun supplier, PDE1 inhibitor, selective PDE1 inhibitor
CAS:
1642303-38-5
Catalog Number:
10-4362
Activity:
Selective PDE1 inhibitor
Chemical Names:
(11R,15S)-5-Anilino-4-[[4-(6-fluoro-2-pyridinyl)phenyl]methyl]-8-methyl-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one phosphate
Alternate Name:
Lenrispodun phosphate
Molecular Weight:
605.57
Molecular Formula:

C29H26FN7O·H3PO4

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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ITI-214 (1642303-38-5) is an ultra-potent and selective inhibitor of phosphodiesterase 1 (PDE1) – Ki = 58 pM.1 Active in various animal models of motor and cognitive functions.1-3 It has also been shown to suppress inflammatory responses 4,5 and improve vascular function5.

References/Citations:

  1. Li al. (2016), Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases; J. Med. Chem., 59 1149
  2. Snyder al. (2016), Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats; Psychopharmacology (Berl), 233 3113
  3. Pekcec al. (2018), Targeting the dopamine D1 receptor or its downstream signalling by inhibiting phosphodiesterase-1 improves cognitive performance; Br. J. Pharmacol., 175 3021
  4. O’Brien al. (2020), Inhibition of calcium-calmodulin phosphodiesterase (PDE1) suppresses inflammatory responses; Mol. Cell Neurosci., 102 103449
  5. Golshiri al. (2021), Selective Phosphodiesterase 1 Inhibition Ameliorates Vascular Function, Reduces Inflammatory Response, and Lowers Blood Pressure in Aging Animals; J. Pharmacol. Exp. Ther., 378 173

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