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Product Details

Ivabradine HCl | Heart failure / unstable angina drug

Ivabradine (148849-67-6) is a clinically useful heart failure and chronic unstable angina medication.1 It lowers heart rate via inhibition of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) expressed in the sinoatrial node (IC50’s: HCN1 = 2.05 µM, HCN2 = 2.29 µM, HCN3 = 2.51 µM, HCN4 = 2.15 µM).2

References/Citations
1) Ide et al. (2019), Ivabradine for the Treatment of Cardiovascular Diseases; Circ. J. 83 252
2) Stieber et al. (2006), Bradycardic and Proarrhythmic Properties of Sinus Node Inhibitors; Mol. Pharmacol. 69 1328

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Catalog#  10-2694-0010

$49.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1448849-67-6
Catalog Number:
10-2694
Activity:
Heart failure / unstable angina drug
Chemical Name:
3-[3-[[(7S)-3,4-Dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride
Molecular Weight:
505.05
Molecular Formula:
C27H36N2O5 • HCl
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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