IWP-4 | Wnt/Porcn inhibitor

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25 mg$175.00
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IWP-4 (686772-17-8) is an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC50=25 nM) by inhibition of the O-palmitoyltransferase Porcn.1 Induces cardiomyocyte differentiation from human pluripotent stem cells.2,3 An important tool for probing the involvement of the Wnt pathway in physiological processes.4 Cell permeable.

References/Citations:

  1. Chen et al. (2009), Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer; Nat. Chem. Biol. 5 100
  2. Lian et al. (2012), Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling; Proc. Natl. Acad. Sci. USA 109 1848
  3. Muneer et al. (2023), Wnt signaling pathway inhibitor promotes mesenchymal stem cells differentiation into cardiac progenitor cells in vitro and improves cardiomyopathy in vivo; World J. Stem Cells 15 821
  4. Zhao et al. (2022), LINC02381, a sponge of miR-21, weakens osteogenic differentiation of hUC-MSCs through KLF12-mediated Wnt4 transcriptional repression; J. Bone Metab. 40 66
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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

IWP-4 (686772-17-8) is an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC50=25 nM) by inhibition of the O-palmitoyltransferase Porcn.1 Induces cardiomyocyte differentiation from human pluripotent stem cells.2,3 An important tool for probing the involvement of the Wnt pathway in physiological processes.4 Cell permeable.

References/Citations:

  1. Chen et al. (2009), Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer; Nat. Chem. Biol. 5 100
  2. Lian et al. (2012), Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling; Proc. Natl. Acad. Sci. USA 109 1848
  3. Muneer et al. (2023), Wnt signaling pathway inhibitor promotes mesenchymal stem cells differentiation into cardiac progenitor cells in vitro and improves cardiomyopathy in vivo; World J. Stem Cells 15 821
  4. Zhao et al. (2022), LINC02381, a sponge of miR-21, weakens osteogenic differentiation of hUC-MSCs through KLF12-mediated Wnt4 transcriptional repression; J. Bone Metab. 40 66