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Product Details

IWR-1 endo | Wnt signaling inhibitor

IWR-1 endo (1127442-82-3) is a potent inhibitor of Wnt signaling (IC50=180 nM).1 Inhibits zebrafish tailfin regeneration (0.5 mM).2 Acts via inhibition of tankyrase and attenuates Wnt/β-catenin signaling in cancer stem-like cells.3 Promotes self-renewal and maintains pluripotency of human embryonic stem cells.4 Promotes differentiation of pluripotent stem cells into cardiomyocytes.5

References/Citations

1) Chen et al. (2009), Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer; Nature Chem. Biol., 5 100
2) Lu et al. (2009), Structure-activity Relationship Studies of Small-Molecule Inhibitors of Wnt Response; Bioorg. Med. Chem. Lett., 19 3825
3) Martins-Neves et al. (2018), IWR-1, a tankyrase inhibitor, attenuates Wnt/ß-catenin signaling in cancer stem-like cells and inhibits in vivo the growth of subcutaneous human osteoxsarcoma xenograft; Cancer Lett., 414 1
4) Kim et al. (2013), Modulations of ß-catenin function matains mouse epiblast stem cell and human embryonic stem cell self-renewal; Nature Commun., 4 4403
5) Ren et al. (2011), Small Molecule Wnt Inhibitors Enhance the Efficiency of BMP-4-directed Cardiac Differentiation of Human Pluripotent Stem Cells; J. Mol. Cell. Cardiol., 51 280

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Catalog#  10-5081-0005

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1127442-82-3
Catalog Number:
10-5081
Activity:
Wnt signaling inhibito
Molecular Weight:
409.44
Molecular Formula:
C25H19N3O2
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
Off-white or yellow solid
Purity:
98% by TLC/HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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