JP-2-196 | Molecular Glue handle

CAS:
 2913587-31-0
Catalog Number:
 10-3938

Available Options

Size:PriceQuantity 
10 mg$100.00
50 mg$350.00

JP-2-196 (2913587-31-0) is a unique molecular glue chemical handle that binds several RING E3 ligases including RNF126, RNF40, MID2, RNF219, RNF14, and LRSAM1. Has been shown to induce proteasomal degradation of a wide variety of proteins when linked to the appropriate ligand.

References/Citations:

  1. Toriki et al. (2023), Rational Chemical Design of Molecular Glue Degraders; ACS Cent. Sci. 9 915
CAS:
2913587-31-0
Catalog Number:
10-3938
Activity:
Molecular Glue handle
Chemical Names:
1-(4-Methoxyphenyl)-4-(1-piperazinyl)-2-butene-1,4-dione trifluoroacetate
Molecular Weight:
388.34
Molecular Formula:

C15H18N2O3·C2HF3O2

Solubility:
Soluble in DMSO (50 mg/mL)
Physical Properties:
Pale yellow solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored @ -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee