OTUDin3 | OTUD3 inhibitor
CAS:
441290-65-9
Catalog Number:
10-4981
Ubiquitin/Proteasome
The ubiquitin-proteasome system (UPS) is a major intracellular protein degradation system in eukaryotes. Damaged, misfolded, or superfluous proteins are labeled with multiple ubiquitin molecules (a 76 amino acid peptide) via the sequential action of E1 activating enzyme, E2 conjugating enzyme, and E3 ligase ultimately leading to destruction of the protein by the 26S proteasome. Deubiquitinases cleave the bond between ubiquitin and protein. Dysregulation of the UPS and/or DUBs is implicated in many neurological disorders, cancer, atherosclerosis and other pathological states.
DUBS
iBAP-II | BAP1 inhibitor
CAS:
1013813-81-4
Catalog Number:
10-4038
Activity:
BAP1 inhibitor
Chemical Names:
4-(8-Nitro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-yl)phenol
Molecular Weight:
308.33
Molecular Formula:
C18H16N2O3
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
P22077 | Selective USP7 inhibitor
CAS:
1247819-59-5
Catalog Number:
10-4125
Activity:
Selective USP7 inhibitor
Chemical Name:
1-(5-((2,4-Difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone
Molecular Weight:
315.32
Molecular Formula:
C12H7F2NO3S2
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
E3 Ubiquitin ligases
Indisulam | RBM39 Molecular glue
CAS:
165668-41-7
Catalog Number:
10-3927
Iberdomide | Cereblon modulator/Molecular glue
CAS:
1323403-33-3
Catalog Number:
10-3921
CC-90009 | Cereblon modulator/Molecular glue
CAS:
1860875-51-9
Catalog Number:
10-3922
Other ligases
TRIM-473 | RING ligase TRIM58 ligand
CAS:
N/A
Catalog Number:
10-4042
PROTACS
Proteasome
Z-Leu-Leu-Leu-vinylsulfone | Proteasome inhibitor
CAS:
193482-47-2
Catalog Number:
10-4990
Gliotoxin | Immunomodulator
CAS:
67-99-2
Catalog Number:
10-2076
Activity:
Immunomodulator
Chemical Names:
(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino
[1,2-a]indole-1,4-dione; Aspergillin
Molecular Weight:
326.39
Molecular Formula:
C13H14N2O4S2
Solubility:
Soluble in DMSO (up to 15 mg/ml)
Physical Properties:
White lyophilized solid
White lyophilized solid
Purity:
98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 yeara as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
ML241 | p97 AAA ATPase inhibitor
CAS:
1346528-06-0
Catalog Number:
10-1555
Activity:
p97 AAA ATPase inhibitor
Chemical Name:
N-Benzyl-2-(2,3-dihydro-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine
Alternate Name:
CID49830260
Molecular Weight:
372.46
Molecular Formula:
C23H24N4O
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 14 mg/ml with warming).
Physical Properties:
Pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Ubiquitin-like modifiers
NAcM-OPT | NEDD8 ligation inhibitor
CAS:
2089293-61-6
Catalog Number:
10-1636
Activity:
NEDD8 ligation inhibitor
Chemical Name:
1-Benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea
Molecular Weight:
434.40
Molecular Formula:
C23H29Cl2N3O
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC/TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as from date of purchase supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
MLN4924 | NEDD8 activating enzyme inhibitor
CAS:
905579-51-3
Catalog Number:
10-1311
Activity:
NEDD8 activating enzyme inhibitor
Chemical Name:
((1S,2S,4R)-4-(4-(((S)-2,3-Dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate; Pevonedistat
Molecular Weight:
443.53
Molecular Formula:
C21H25N5O4S
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Ubiquitin activating enzyme
ML-792 | SUMO-activating enzyme inhibitor
CAS:
1644342-14-2
Catalog Number:
10-4985
Pyr41 | E1 UAE inhibitor
CAS:
418805-02-4
Catalog Number:
10-1304
Activity:
E1 UAE inhibitor
Chemical Name:
4-[4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester
Molecular Weight:
371.31
Molecular Formula:
C17H13N3O7
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Brown solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Shipping Code:
RT
Other
E7820 | RBM39 molecular glue
CAS:
289483-69-8
Catalog Number:
10-3935
EN450 | NFkB1 molecular glue
CAS:
793719-01-4
Catalog Number:
10-3936
SJ6986 | GSPT1 molecular glue
CAS:
2765625-93-0
Catalog Number:
10-3933
