JQ1-PA | BET-bromodomain click ligand

JQ1-PA chemical structure

Available Options

Size:PriceQuantity 
5 mg$65.00
25 mg$260.00
Request Quote / Bulk / Custom Size
Product Inquiry

JQ1-PA (2115701-93-2) is an alkyne-linked analog of the BET-bromodomain inhibitor JQ1. It can be used to create PROTACs targeting BET-bromodomains by click-conjugating with various E3 ligase ligands.  It can also be click-conjugated to fluorescent dyes for imaging applications.  JQ1-PA can be used to harness BET-bromodomain nuclear import activity. When conjugated to an antisense oligonucleotide (ASO), it enhances nuclear accumulation which drives increased potency and efficacy of ASOs.2

References/Citations:

  1. Tyler et al. (2017), Click chemistry enables preclinical evaluation of targeted epigenetic therapies; Science 356 1397
  2. Kashyap et al. (2025), Harnessing BET-Bromodomain Assisted Nuclear Import for Targeted Subcellular Localization and Enhanced Efficacy of Antisense Oligonucleotides; J. Am. Chem. Soc. 147 29478
2115701-93-2, BET-bromodomain click ligand, JQ1 click ligand, JQ1-PA, JQ1-PA supplier
Alternate Name:
(+)-JQ1-PA

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

JQ1-PA (2115701-93-2) is an alkyne-linked analog of the BET-bromodomain inhibitor JQ1. It can be used to create PROTACs targeting BET-bromodomains by click-conjugating with various E3 ligase ligands.  It can also be click-conjugated to fluorescent dyes for imaging applications.  JQ1-PA can be used to harness BET-bromodomain nuclear import activity. When conjugated to an antisense oligonucleotide (ASO), it enhances nuclear accumulation which drives increased potency and efficacy of ASOs.2

References/Citations:

  1. Tyler et al. (2017), Click chemistry enables preclinical evaluation of targeted epigenetic therapies; Science 356 1397
  2. Kashyap et al. (2025), Harnessing BET-Bromodomain Assisted Nuclear Import for Targeted Subcellular Localization and Enhanced Efficacy of Antisense Oligonucleotides; J. Am. Chem. Soc. 147 29478