K-975 | YAP/TAZ-TEAD signaling inhibitor

CAS:
 2563855-03-6
Catalog Number:
 10-4297

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K-975 (2563855-03-6) is a covalent inhibitor of YAP/TAZ-TEAD signaling. It binds to the palmitate-binding pocket of TEAD preventing its association with YAP/TAZ.1 K-975 inhibited proliferation of NF2-non-expressing mesothelioma cell lines.  K-975 promoted liver progenitor cell to hepatocyte differentiation via suppression of YAP signaling.2 It sensitized YAP-expressing RET-aberrant cancer cells to RET kinase inhibitors.3

  1. Kaneda et al. (2020), The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma; Am. J. Cancer Res. 10 4399
  2. Kim et al. (2023), PPARα activation promotes liver progenitor cell-mediated liver regeneration by suppressing YAP signaling in zebrafish; Sci. Rep. 13 18312
  3. Katayama et al. (2025), YAP Regulates HER3 Signaling-Driven Adaptive Resistance to RET Inhibitors in RET-Aberrant Cancers; Clin. Cancer Res. 31 1127
2563855-03-6, K-975, K-975 supplier, K975, TEAD signaling inhibitor, YAP/TAZ signaling inhibitor
CAS:
2563855-03-6
Catalog Number:
10-4297
Activity:
YAP/TAZ-TEAD signaling inhibitor
Chemical Names:
N-[3-(4-Chlorophenoxy)-4-methylphenyl]prop-2-enamide
Alternate Name:
N-[3-(4-Chlorophenoxy)-4-methylphenyl]acrylamide
Molecular Weight:
287.74
Molecular Formula:

C16H14ClNO2

Solubility:
Soluble in DMSO (>50 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ room temperature. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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K-975 (2563855-03-6) is a covalent inhibitor of YAP/TAZ-TEAD signaling. It binds to the palmitate-binding pocket of TEAD preventing its association with YAP/TAZ.1 K-975 inhibited proliferation of NF2-non-expressing mesothelioma cell lines.  K-975 promoted liver progenitor cell to hepatocyte differentiation via suppression of YAP signaling.2 It sensitized YAP-expressing RET-aberrant cancer cells to RET kinase inhibitors.3

  1. Kaneda et al. (2020), The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma; Am. J. Cancer Res. 10 4399
  2. Kim et al. (2023), PPARα activation promotes liver progenitor cell-mediated liver regeneration by suppressing YAP signaling in zebrafish; Sci. Rep. 13 18312
  3. Katayama et al. (2025), YAP Regulates HER3 Signaling-Driven Adaptive Resistance to RET Inhibitors in RET-Aberrant Cancers; Clin. Cancer Res. 31 1127

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