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Product Details

KC7F2 | HIF-1alpha inhibitor

KC7F2 is an inhibitor of HIF-1α (IC50 = 20 µM).1 It inhibited HIF-mediated transcription in cells derived from glioma, breast, and prostate cancers. The mechanism of action of KC7F2 is via down-regulation of HIF-1α protein synthesis accompanied by suppression of phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 and p70 S6 kinase, key regulators of HIF-1α protein synthesis.

References/Citations

1)Narita et al. (2009), Identification of a Novel Small Molecule HIF-1α Translation Inhibitor; Clin. Cancer Res. 15 6128

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Catalog#  10-4714-0010

$60.00
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CAS:
927822-86-4
Catalog Number:
10-4714
Activity:
HIF-1alpha inhibitor
Chemical Name:
N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
Molecular Weight:
570.38
Molecular Formula:
C16H16Cl4N2O4S4
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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