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Ketoconazole | Cytochrome P450 inhibitor

Ketoconazole (65277-42-1) is a broad spectrum antifungal agent acting via inhibition of cytochrome P450 14-α-demethylase.1 Ketoconazole has been shown to inhibit CYP3A and CYP1A1.2

References/Citations
1) Loose et al. (1983) Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes; J. Clin. Invest. 71 1495
2) Sai et al. (2000) Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450. Xenobiotica 30 327

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Focus Biomolecules cell signaling reagent supplier, structure Ketoconazole | Cytochrome P450 inhibitor | CAS 65277-42-1

Catalog#  10-1015-0100

$40.00
Quantity
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CAS:
65277-42-1
Catalog Number:
10-1015
Activity:
Cytochrome P450 inhibitor
Chemical Name:
(±)-1-[4-(4-{[-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one
Molecular Weight:
531.43
Molecular Formula:
C26H28Cl2N4O4
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Off-white solid
Purity:
>98% by TLC
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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