Kynurenine (L) | Endogenous AhR agonist
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 20 mg | $38.00 | ||
| 100 mg | $88.00 |
Kynurenine (2922-83-0) is a tryptophan catabolite.1 Endogenous tumor-promoting ligand of the human aryl hydrocarbon receptor (AhR). Constitutively generated by human tumor cells via the action of the tryptophan degrading enzyme, tryptophan-2,3-dioxygenase (TDO). Kynurenine suppresses antitumor immune responses and promotes tumor cell survival and motility.2
References/Citations
1) Ibana et al. (2011), Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlaydia trachomatis persistence in human epithelial cells; Infect. Immun., 79 4425
2) Opitz et al. (2011), An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor; Nature, 478 197
NMR (Conforms)
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Product Data Sheet:
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Kynurenine (2922-83-0) is a tryptophan catabolite.1 Endogenous tumor-promoting ligand of the human aryl hydrocarbon receptor (AhR). Constitutively generated by human tumor cells via the action of the tryptophan degrading enzyme, tryptophan-2,3-dioxygenase (TDO). Kynurenine suppresses antitumor immune responses and promotes tumor cell survival and motility.2
References/Citations
1) Ibana et al. (2011), Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlaydia trachomatis persistence in human epithelial cells; Infect. Immun., 79 4425
2) Opitz et al. (2011), An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor; Nature, 478 197
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