L-755,507 | ß3 adrenergic agonist/CRISPR efficiency enhancer
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $95.00 | ||
| 25 mg | $350.00 |
L-755,507 (159182-43-1) is a very potent (EC50 = 0.43 nM; IC50 = 13 nM) human ß3 adrenergic receptor agonist with >440-fold selectivity of ß1/2.1 It elicited lipolysis and metabolic rate elevation in rhesus monkeys.2 L-755,507 has been shown to increase homology-directed repair efficiency by 2- and 3-fold in CRISPR gene editing.3,4
References/Citations:
- Parmee et al. (1998), Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist; Bioorg. Med. Chem. Lett. 8 1107
- Fisher et al. (1998), A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys; J. Clin. Invest. 101 2387
- Li et al. (2017), Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells; Sci. Rep. 7 8943
- Yu et al. (2015), Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells; Cell Stem Cell 16 142
C30H40N4O6S
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
L-755,507 (159182-43-1) is a very potent (EC50 = 0.43 nM; IC50 = 13 nM) human ß3 adrenergic receptor agonist with >440-fold selectivity of ß1/2.1 It elicited lipolysis and metabolic rate elevation in rhesus monkeys.2 L-755,507 has been shown to increase homology-directed repair efficiency by 2- and 3-fold in CRISPR gene editing.3,4
References/Citations:
- Parmee et al. (1998), Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist; Bioorg. Med. Chem. Lett. 8 1107
- Fisher et al. (1998), A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys; J. Clin. Invest. 101 2387
- Li et al. (2017), Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells; Sci. Rep. 7 8943
- Yu et al. (2015), Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells; Cell Stem Cell 16 142
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