L-Cycloserine | Serine palmitoyltransferase inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 20 mg | $50.00 | ||
| 100 mg | $140.00 |
L-Cycloserine (339-72-0) down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase).1 The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme.1 It is a useful pharmacological agent for lowering sphingolipid levels in cells2 as well as in animal models3. Inhibition of de novo ceramide biosynthesis with L-cycloserine positively affected the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in a cortical neuronal model of senescence.4
References/Citations:
- Sundaram et al. (1984), Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo; J. Neurochem. 42 577
- Ribbens et al. (2014), Characterization and application of a disease-cell model for a neurodegenerative lysosomal disease; Mol. Genet. Metab., 111 172
- Lewandowski et al. (2022), Inhibition of ceramide accumulation in AdipoR-/- mice increases photoreceptor survival and improves vision; JCI Insight 7 e156301
- Granzotto et al. (2019), Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence; Aging (Albany NY) 11 6336
C3H6N2O2
>98% by TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
L-Cycloserine (339-72-0) down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase).1 The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme.1 It is a useful pharmacological agent for lowering sphingolipid levels in cells2 as well as in animal models3. Inhibition of de novo ceramide biosynthesis with L-cycloserine positively affected the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in a cortical neuronal model of senescence.4
References/Citations:
- Sundaram et al. (1984), Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo; J. Neurochem. 42 577
- Ribbens et al. (2014), Characterization and application of a disease-cell model for a neurodegenerative lysosomal disease; Mol. Genet. Metab., 111 172
- Lewandowski et al. (2022), Inhibition of ceramide accumulation in AdipoR-/- mice increases photoreceptor survival and improves vision; JCI Insight 7 e156301
- Granzotto et al. (2019), Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence; Aging (Albany NY) 11 6336
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