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Cellular Senescence

  • ABT-263 | Bcl-2 family inhibitor; Senolytic agent

    CAS:
    923564-51-6
    Catalog Number:
    10-3141
    Activity:
    Bcl-2 family inhibitor; Senolytic agent
    Chemical Name:
    4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)- 3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-benzamide
    Alternate Name:
    Navitoclax
    Molecular Weight:
    974.61
    Molecular Formula:
    C47H55ClF3N5O6S3
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
    From $60.00
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  • ABT-737 | Senolytic Bcl2 inhibitor

    CAS:
    852808-04-9
    Catalog Number:
    10-3661
    Activity:
    Senolytic Bcl inhibitor
    Chemical Names:
    4-[4-[(4′-Chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide
    Molecular Weight:
    813.43
    Molecular Formula:
    C42H45ClN6O5S2
    Solubility:
    Soluble in DMSO (5 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $80.00
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  • Cycloastragenol | Telomerase activator/Senolytic agent

    Cycloastragenol (84605-18-5) is a novel naturally occurring terpenoid found in Astragalus which was shown to be a telomerase activator.  In CD8+ T lymphocytes from HIV-infected donors […]

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  • Dasatinib | Src and Bcr/Abl inhibitor

    CAS:
    302962-49-8
    Catalog Number:
    10-2126
    Activity:
    Src and Bcr/Abl inhibitor
    Alternate Names:
    BMS-354825
    Chemical Name:
    N-(2-Chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide
    Molecular Weight:
    488.01
    Molecular Formula:
    C22H26ClN7O2S
    Solubility:
    Soluble in DMSO (up to 200 mg/ml).
    Physical Properties:
    White or off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
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  • JPH203 | LAT1 inhibitor

    CAS:
    1597402-27-1
    Catalog Number:
    10-4464
    Activity:
    LAT1 inhibitor
    Chemical Names:
    (2S)-2-Amino-3-[4-[(5-amino-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-dichlorophenyl]propanoic acid dihydrochloride
    Alternate Name:
    KYT-0353; Nanvuralant
    Molecular Weight:
    545.24
    Molecular Formula:
    C23H19Cl2N3O4·2HCl
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Pale orange/yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $95.00
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Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

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