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L-Ergothioneine | Antioxidant - endogenous

L-Ergothioneine (CAS 497-30-3) is a naturally occurring ubiquitous antioxidant which is found in many cells at concentrations up to 2 mM.1 Rescues PC12 cells from β-amyloid-induced apoptotic cell death.2 Protects against cisplatin-induced neuronal injury and enhances cognition in a mouse model.3 Interferes with endothelial cell senescence.4


1) Cheah and Halliwell (2012), Ergothioneine: antioxidant potential, physiological function and role in disease; Biochim. Biophys. Acta, 1822 784
2) Jang et al. (2004), Ergothioneine rescues PC12 cells from beta-amyloid-induced apoptotic death; Free Radic. Biol. Med., 36 288
3) Song et al. (2010), Ergothioneine protects against neuronal injury induced by cisplatin both in vitro and in vivo; Food Chem. Toxicol. 48 3492
4) D’Onofrio et al. (2016), Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6; Free Radic. Biol. Med., 96 211

Focus Biomolecules cell signaling supplier, chemical structure of L-Ergothioneine | Antioxidant - endogenous | CAS 497-30-3

Catalog#  10-3012-0005

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Catalog Number:
Antioxidant - endogenouse
Chemical Name:
(α-S)-α-Carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-1H-imidazole-4-ethanaminium inner salt
Alternate Names:
2-Mercaptohistidine betaine; NSC-7175
Molecular Weight:
Molecular Formula:
Soluble in Water (up to 10 mg/ml)
Physical Properties:
White or off-white solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in water may be stored at -20°C for no more then 1 day.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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