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Product Details

Lapatinib (base) | EGFR and HER2 inhibitor

Lapatinib (231277-92-2) is a potent inhibitor of EGFR kinase (Ki=3 nM), Erb-2 kinase (Ki=13 nM) Erb-4 kinase (Ki=347 nM).1  Clinically useful agent for treatment of breast cancer.2-3 Cell permeable

References/Citations

1) Wood et al. (2004), A unique structure for epidermal growth fsctor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells;  Cancer Res., 64 6652
2) Burris et al. (2004), Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib;  Oncologist, 9 10
3) Chu et al. (2005), The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016) cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer;  Cancer Res., 65 18

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Catalog#  10-2147

$50.00
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CAS:
231277-92-2
Catalog Number:
10-2147
Activity:
EGFR and HER2 inhibitor
Chemical Name:
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine
Alternate Names:
GW-572016
Molecular Weight:
581.06
Molecular Formula:
C29H26ClFN4O4S
Solubility:
Soluble in DMSO (up to 200 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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