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Lapatinib (base) | EGFR and HER2 inhibitor

CAS:
231277-92-2
Catalog Number:
10-2147
Activity:
EGFR and HER2 inhibitor
Chemical Name:
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine
Alternate Names:
GW-572016
Molecular Weight:
581.06
Molecular Formula:
C29H26ClFN4O4S
Solubility:
Soluble in DMSO (up to 200 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Lapatinib (231277-92-2) is a potent inhibitor of EGFR kinase (Ki=3 nM), Erb-2 kinase (Ki=13 nM) Erb-4 kinase (Ki=347 nM).1  Clinically useful agent for treatment of breast cancer.2,3 Cell permeable

References/Citations:

1) Wood et al. (2004), A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells;  Cancer Res., 64 6652
2) Burris et al. (2004), Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib;  Oncologist, 9 10
3) Chu et al. (2005), The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016) cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer;  Cancer Res., 65 18

Lapatinib (base) | EGFR and HER2 inhibitor is also available in the Cellular Metabolism Library.
CAS:
231277-92-2
Catalog Number:
10-2147
Activity:
EGFR and HER2 inhibitor
Chemical Name:
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine
Alternate Names:
GW-572016
Molecular Weight:
581.06
Molecular Formula:
C29H26ClFN4O4S
Solubility:
Soluble in DMSO (up to 200 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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