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Leonurine | Neuroinflammation inhibitor

Leonurine (CAS 24697-74-3) inhibits microglial overactivation and attenuates Aβ(1-40)-induced cognitive impairments in rats via JNK and NF-κB pathways.1 Inhibits the formation of advanced glycation end products.2 Ameliorates cognitive dysfunction by antagonizing exocytotoxic glutamate insults and inhibiting autophagy.3 Attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4.4 Attenuates early atherosclerotic lesions in hypercholesterolemic rabbits via modulation of the inflammatory and oxidative stress pathways.5

References/Citations

1) Hong et al. (2014), SCM-198 inhibits microglial overactivation and attenuates AB(1-40)-induced cognitive impairments in rats via JNK and NF-kB pathways; J. Neuroinflammation, 11 147
2) Huang et al. (2015), Inhibitory effect of leonurine on the formulation of advanced glycation end products; Food Funct., 6 584
3) Liu et al. (2016), Leonurine ameliorates cognitive dysfunction via antagonizing excitotoxic glutamate insults and inhibiting autophagy; Phytomedicine, 23 1638
4) Liu et al. (2013), Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4; Free Radic. Biol. Med., 54 93
5) Zhang et al. (2012), SCM-198 attenuates early atherosclerotic lesions in hypercholesterolemic rabbits via modulations of the inflammatory and oxidative stress pathways; Atherosclerosis, 224 43

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Focus Biomolecules cell signaling supplier, chemical structure of Leonurine | Neuroinflammation inhibitor | CAS 24697-74-3

Catalog#  10-3193-0010

$48.00
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CAS:
24697-74-3
Catalog Number:
10-3193
Activity:
Neuroinflammation inhibitor
Chemical Name:
4-guanidinobutyl 4-hydroxy-3,5-dimethoxybenzoate
Alternate Names:
SCM-198
Molecular Weight:
311.33
Molecular Formula:
C14H21N3O5
Solubility:
Soluble in DMSO (up to 30 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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