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Leupeptin hemisulfate | Trypsin-like cysteine protease inhibitor

Leupeptin hemisulfate (103476-89-7) is a reversible inhibitor of trypsin-like proteases and cysteine proteases. Inhibits trypsin, plasmin, papain and cathepsin B, H and L.1-3 Blocks various apoptotic pathways in T cells.4 Commonly used in cell lysis buffers to protect proteins from degradation. Typical working concentration is 1µM (0.5 µg/ml).

References/Citations

1) Aoyagi et al. (1969), Leupeptins, new protease inhibitors from Actinomycetes; J. Antibiot., 22 283
2) Barrett et al. (1981), Cathepsin B, Cathepsin H and Cathepsin L; Methods Enzymol., Pt C, 80 535
3) Knight et al. (1980), Human cathepsin B. Application of the substrate N-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide to a study of the inhibition by leupeptin; Biochem. J., 189 447
4) Sarin et al. (1995), A protease-dependent TCR-induced death pathway in mature lymphocytes; J. Immunol., 154 5806

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Focus Biomolecules, chemical structure of Leupeptin hemisulfate | Trypsin-like cysteine protease inhibitor | CAS 103476-89-7

Catalog#  10-1346-0025

$80.00
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CAS:
103476-89-7
Catalog Number:
10-1346
Activity:
Trypsin-like cysteine protease inhibitor
Alternate Names:
Ac-Leu-Leu-Arg-CHO, hemisulfate
Molecular Weight:
475.59
Molecular Formula:
C20H38N6O4 &bul; 1/2H2SO4
Solubility:
Soluble in Water (up to 50 mg/ml). Also soluble in ethanol and methanol
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied Solutions in distilled water, ethanol or methanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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