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LH-846 | Casein kinase 1 delta inhibitor

LH-846 (639052-78-1) is a potent and selective inhibitor of casein kinase (CK) 1δ., IC50s=0.29, 1.3 and 2.5 μM for δ, ε and α isoforms respectively with no inhibition of CK2. Inhibits CK1δ-mediated phosphorylation and degradation of PER1 protein and lengthens circadian period in U2OS cells.1

References/Citations

1) Lee et al. (2011), A small molecule modulates circadian rhythms through phosphorylation of the period protein; Agnew Chem. Int. ed. Engl., 50 10608

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Focus Biomolecules cell signaling supplier, chemical structure of LH-846 | Casein kinase 1 delta inhibitor | CAS 639052-78-1

Catalog#  10-1465-0005

$55.00
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CAS:
639052-78-1
Catalog Number:
10-1465
Activity:
Casein kinase 1 delta inhibitor
Chemical Name:
N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneaceramide
Molecular Weight:
316.81
Molecular Formula:
C16H13ClN2OS
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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