Linopirdine dihydrochloride | Kv7 Blocker

CAS:
 113168-57-3
Catalog Number:
 10-4654
Linopirdine chemical structure Focus Biomolecules

Available Options

Size:PriceQuantity 
5 mg$70.00
25 mg$225.00

Linopirdine (113168-57-3) increases acetylcholine release and improves performance in animal models of learning and memory via blockade of Kv7 (KCNQ) voltage-gated potassium channels.1-3 Linopirdine is a state-dependent blocker favoring activated single subunits of the channel.4 It has also been shown to act as an agonist of TRPV1.5

References/Citations:

  1. Kristufek (1999), Modulation of spontaneous and stimulation-evoked transmitter release from rat sympathetic neurons by the cognition enhancer linopirdine: insights into its mechanisms of action; J. Neurochem. 72 2083
  2. Wang et al. (1998), KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel; Science 282 1890
  3. Fontana et al. (1994), Linopirdine (DuP 996) improves performance in several tests of learning and memory by modulation of cholinergic neurotransmission; Pharmacol. Biochem. Behav. 49 1075
  4. Greene et al. (2017), XE991 and Linopirdine Are State-Dependent Inhibitors of Kv7/KCNQ Channels that Favor Activated Subunits; J. Pharmacol. Exp. Ther. 362 177
  5. Neascu and Babes (2010), The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1; J. Pharmacol. Sci. 114 332
CAS:
113168-57-3
Catalog Number:
10-4654
Activity:
Kv7 Blocker
Chemical Names:
1-Phenyl-3,3-bis(pyridine-4-ylmethyl)indolin-2-one dihydrochloride
Alternate Name:
DuP 996
Molecular Weight:
464.39
Molecular Formula:

C26H21N3O·2HCl

Solubility:
Soluble in DMSO (>25 mg/ml); Water (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:

98% by HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!