Linopirdine dihydrochloride | Kv7 Blocker
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $225.00 |
Linopirdine (113168-57-3) increases acetylcholine release and improves performance in animal models of learning and memory via blockade of Kv7 (KCNQ) voltage-gated potassium channels.1-3 Linopirdine is a state-dependent blocker favoring activated single subunits of the channel.4 It has also been shown to act as an agonist of TRPV1.5
References/Citations:
- Kristufek (1999), Modulation of spontaneous and stimulation-evoked transmitter release from rat sympathetic neurons by the cognition enhancer linopirdine: insights into its mechanisms of action; J. Neurochem. 72 2083
- Wang et al. (1998), KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel; Science 282 1890
- Fontana et al. (1994), Linopirdine (DuP 996) improves performance in several tests of learning and memory by modulation of cholinergic neurotransmission; Pharmacol. Biochem. Behav. 49 1075
- Greene et al. (2017), XE991 and Linopirdine Are State-Dependent Inhibitors of Kv7/KCNQ Channels that Favor Activated Subunits; J. Pharmacol. Exp. Ther. 362 177
- Neascu and Babes (2010), The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1; J. Pharmacol. Sci. 114 332
C26H21N3O·2HCl
98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Linopirdine (113168-57-3) increases acetylcholine release and improves performance in animal models of learning and memory via blockade of Kv7 (KCNQ) voltage-gated potassium channels.1-3 Linopirdine is a state-dependent blocker favoring activated single subunits of the channel.4 It has also been shown to act as an agonist of TRPV1.5
References/Citations:
- Kristufek (1999), Modulation of spontaneous and stimulation-evoked transmitter release from rat sympathetic neurons by the cognition enhancer linopirdine: insights into its mechanisms of action; J. Neurochem. 72 2083
- Wang et al. (1998), KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel; Science 282 1890
- Fontana et al. (1994), Linopirdine (DuP 996) improves performance in several tests of learning and memory by modulation of cholinergic neurotransmission; Pharmacol. Biochem. Behav. 49 1075
- Greene et al. (2017), XE991 and Linopirdine Are State-Dependent Inhibitors of Kv7/KCNQ Channels that Favor Activated Subunits; J. Pharmacol. Exp. Ther. 362 177
- Neascu and Babes (2010), The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1; J. Pharmacol. Sci. 114 332
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