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Lipofermata | Fatty acid transport protein 2 (FATP2) inhibitor

Lipofermata (297180-15-5) is an inhibitor of fatty acid transport protein 2 (FATP2; IC50 = 4.84 µM).1 It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase. It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease.2 Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.3

References/Citations
1) Sandoval et al. (2010), Identification and characterization of small compound inhibitors of human FATP2; Biochem. Pharmacol. 79 990
2) Ahowesso et al. (2015), Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death; Biochem. Pharmacol. 98 167
3) Zhang et al. (2018), Adipocyte-derived lipids mediate melanoma progression via FATP proteins; Cancer Discov. 8 1006
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Catalog#  10-3902-0010

$65.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
297180-15-5
Catalog Number:
10-3902
Activity:
Fatty acid transport protein 2 (FATP2) inhibitor
Chemical Name:
5-Bromo-5’phenylspiro[1H-indole-3,2’-3H-1,3,4-thiadiazole]-2-one
Alternate Name:
CB16.2
Molecular Weight:
360.23
Molecular Formula:
C15H10BrN3OS
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Off-white solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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