Lipofermata | Fatty acid transport protein 2 (FATP2) inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $65.00 | ||
| 50 mg | $225.00 |
Lipofermata (297180-15-5) is an inhibitor of fatty acid transport protein 2 (FATP2; IC50 = 4.84 µM).1 It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase. It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease.2 Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.3
References/Citations:
1) Sandoval et al. (2010), Identification and characterization of small compound inhibitors of human FATP2; Biochem. Pharmacol. 79 990
2) Ahowesso et al. (2015), Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death; Biochem. Pharmacol. 98 167
3) Zhang et al. (2018), Adipocyte-derived lipids mediate melanoma progression via FATP proteins; Cancer Discov. 8 1006
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NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Lipofermata (297180-15-5) is an inhibitor of fatty acid transport protein 2 (FATP2; IC50 = 4.84 µM).1 It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase. It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease.2 Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.3
References/Citations:
1) Sandoval et al. (2010), Identification and characterization of small compound inhibitors of human FATP2; Biochem. Pharmacol. 79 990
2) Ahowesso et al. (2015), Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death; Biochem. Pharmacol. 98 167
3) Zhang et al. (2018), Adipocyte-derived lipids mediate melanoma progression via FATP proteins; Cancer Discov. 8 1006
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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