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Product Details

Lisofylline (racemic) | Anti-diabetic and Antiinflammatory agent

Lisofylline (6493-06-7, racemic) displays anti-inflammatory activity. Regulates immune cell function and autoimmune response by inhibition of IL-12 signalling and cytokine production1. Protects pancreatic beta cells and prevents type I diabetes in non-obese diabetic mice2. Lisofylline reduces LPS-induced TNF alpha levels in CD-1 mice3. Cell permeable.

References/Citations
1) Yang et al. (2005), Lisofylline: a potential lead for the treatment of diabetes; Biochem. Phamracol., 69 1
2) Yang et al. (2002), The anti-infkammatory compound lisofylline prevents Type I diabetes in non-obese diabetic mice; Diabetologia, 45 1307
3) Wyska et al. (2010), Pharmacokinetic-pharmacodynamic modeling of methylxanthine derivatives in mice challenged with high-dose lipopolysaccharide; Pharmacology, 85 264

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Focus Biomolecules chemical structure Lisofylline (racemic) | Anti-diabetic, Antiinflammatory agent | CAS 6493-06-7

Catalog#  10-2781

$50.00
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CAS:
6493-06-7
Catalog Number:
10-2781
Activity:
Anti-diabetic and Antiinflammatory agent
Alternate Names:
LSF; BL-194
Chemical Name:
1-(5-Hydroxyhexyl)-3,7-dimethylpurine-2,6-dione (racemic)
Molecular Weight:
280.33
Molecular Formula:
C13H20N4O3
Solubility:
Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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