LM22A-4 | TrkB small molecule agonist
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $220.00 |
LM22A-4 (37988-18-4) is a small molecule BDNF mimetic displaying neurotrophhic activity. Partial agonist at TRKB and activates TRKB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with equal efficacy to that of BDNF. After in vivo administraton, LM22A-4 caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats.1 Improves respiratory function in a mouse models of Rett syndrome.2
References/Citations:
1) Massa et al. (2010), Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents; J. Clin. Invest., 120 1774
2) Schmid et al. (2012), A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome; J. Neurosci., 32 1803
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
LM22A-4 (37988-18-4) is a small molecule BDNF mimetic displaying neurotrophhic activity. Partial agonist at TRKB and activates TRKB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with equal efficacy to that of BDNF. After in vivo administraton, LM22A-4 caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats.1 Improves respiratory function in a mouse models of Rett syndrome.2
References/Citations:
1) Massa et al. (2010), Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents; J. Clin. Invest., 120 1774
2) Schmid et al. (2012), A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome; J. Neurosci., 32 1803
Related products
-
AG-1517 HCl | EGFR kinase inhibitor
From $70.00CAS:153436-54-5Catalog Number:10-1377Activity:EGFR kinase inhibitorAlternate Names:PD153,053; SU-5271; Z-252868Chemical Name:4-(3-Bromoanilino)-6,7-dimethoxyquinazoline hydrochlorideMolecular Weight:360.21Molecular Formula:C16H14BrN3O2Solubility:Soluble in DMSO (up to 5 mg/ml).Physical Properties:White or off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
Dovitinib | Multi-kinase inhibitor
From $75.00CAS:405169-16-6Catalog Number:10-2129Activity:Kinase inhibitorAlternate Names:TKI-258, CHIR258Chemical Name:4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-oneMolecular Weight:392.43Molecular Formula:C21H21FN6OSolubility:Soluble in DMSO (up to 30 mg/ml).Physical Properties:Yellow-green solidPurity:99% by TLC
99% by HPLCStorage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
Src-I1 | Src kinase inhibitor
From $60.00CAS:179248-59-0Catalog Number:10-1020Activity:Src kinase inhibitorChemical Name:6,7-Dimethoxy-N-(4-Phenoxyphenyl)-4-quinazolinamineMolecular Weight:373.41Molecular Formula:C22H19N3O3Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:White or off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
