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Lorcainide HCl | Voltage-gated sodium channel blocker

Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na+ channel blocker.1 Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation.2 Acts at the ouabain binding site of guinea pig cardiac Na+/K+ ATPase and inhibits the enzyme (IC50 = 34 μM).3

References/Citations

1) Sheldon et al. (1989), Antiarrhythmic drugs and the cardiac sodium channel: current models; Clin. Chem., 35 748
2) Lynch et al. (1995), Sodium channel clockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists; J. Pharmacol. Exp. Ther., 273 554
3) Almotrefi et al. (1999), Class I antiarrhythmic drug effects on ouabain binding to guinea pig cardiac Na+ -K+ ATPase; Can. J. Physiol. Pharmacol., 77 866

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Focus Biomolecules supplier, chemical structure of Lorcainide HCl | Voltage-gated sodium channel blocker | CAS 58934-46-6

Catalog#  10-1157-0005

$40.00
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CAS:
58934-46-6
Catalog Number:
10-1157
Activity:
Voltage-gated sodium channel blocker
Chemical Name:
N-(4-Chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide hydrochloride
Molecular Weight:
407.38
Molecular Formula:
C22H27ClN2O • HCl
Solubility:
Soluble in DMSO (up to 20 mg/ml), in Water (up to 20 mg/ml), or in Ethanol (up to 20 mg/ml).
Physical Properties:
Powder
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO, distilled water or ethanol may be stored at -20°C for up to 1 month
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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