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Losartan potassium | Angiotensin AT1 antagonist

Losartan potassium (124750-99-8) is a non-peptide angiotensin II receptor antagonist.1,2 Clinically useful antihypertensive agent.3 Inhibits collagen I synthesis.4 Induces SIRT1 expression and activity and reduces hepatic injury in a rat reduced-size orthotopic liver transplantation model.5 Losartan potassium displays neuroprotective effects along with nimesulide (Cat.# 10-1161) against chronic fatigue stress.6 Displays myocardial antifibrotic activity.7

1) Merck 14:5583
2) Chiu et al. (1990), Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent; J. Pharmacol. Exp. Ther., 252 711
3) McIntyre et al. (1997), Losartan, an orally active angiotensin (AT1) receptor antagonist: a review of it's efficacy and safety in essential hypertension; Pharmacol. Ther., 74 181
4) Diop-Frimpong et al. (2011), Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors; Proc. Natl. Acad. Sci. USA, 108 2909
5) Pantazi et al. (2015), Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation; World J. Gastroenterol., 21 8021
6) Kumar et al. (2015), Neuroprotective mechanism of losartan and its interaction with nimesulide against chronic fatigue stress; Inflammopharmacology, 23 291
7) Miguel-Carrasco et al. (2017), Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites; Sci. Rep. 7 41865

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Catalog#  10-2294

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Catalog Number:
Angiotensin AT1 antagonist
Alternate Names:
Chemical Name:
2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol, potassium salt
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Off-white solid
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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