Lycorine HCl | Protein synthesis inhibitor/SCAP degrader
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $38.00 | ||
| 50 mg | $100.00 |
Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 µM).4 A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5
References:
- Miliauskas et al. (2005), Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR; Nat. Prod., 68 168
- Liu et al. (2011), Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication; Virol. J., 8 483
- Onishi et al. (2012), Lycorine, a candidate for the control of period length in mammalian cells; Cell Physiol. Biochem., 29 407
- Cao et al. (2013), Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity; Toxicol. Lett., 218 174
- Zheng et al. (2020), The Paf1 complex transcriptionally regulates the mitochondrial anchored protein Atg32 leading to activation of mitophagy; Autophagy, 20 1
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 µM).4 A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5
References:
- Miliauskas et al. (2005), Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR; Nat. Prod., 68 168
- Liu et al. (2011), Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication; Virol. J., 8 483
- Onishi et al. (2012), Lycorine, a candidate for the control of period length in mammalian cells; Cell Physiol. Biochem., 29 407
- Cao et al. (2013), Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity; Toxicol. Lett., 218 174
- Zheng et al. (2020), The Paf1 complex transcriptionally regulates the mitochondrial anchored protein Atg32 leading to activation of mitophagy; Autophagy, 20 1
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